ASK1 antibody - 100 µL

Alternate_Names : mitogen-activated protein kinase kinase kinase 5 , ASK1 , MAPKKK5 , MEKK5 Applications : ICC | IF | IHC-P | WB Species_reactivity : Hu Storage_Buffer : PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide. Concentration : 1 mg/mlsp Form : mitogen-activated protein kinase kinase kinase 5 , ASK1 , MAPKKK5 , MEKK5 References : Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream p rotein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains . Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-act ivated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]